Ricardo Carvalho returns to the side for the first time in a month, Petr Cech is back and Deco starts.
The Portuguese pair come in for Alex and Juliano Belletti but otherwise, the outfielders are the ones that started at Middlesbrough.
Youth is represented on the bench in the shape of winger Miroslav Stoch and striker Franco Di Santo.
Francesco Totti will play up front for Roma, Mirko Vucinic making way for the captain by moving to the left of a front three.
Simone Perrotta has been ill so is only on the bench with Brazilian Rodrigo Taddei coming in. Former Chelsea loanee Christian Panucci is in central defence.
Chelsea will line-up in a 4-1-4-1 formation as follows:
1 Petr Cech
17 José Bosingwa
6 Ricardo Carvalho
26 John Terry (c)
18 Wayne Bridge
12 John Mikel Obi
21 Salomon Kalou
20 Deco
8 Frank Lampard
15 Florent Malouda
39 Nicolas Anelka
Substitutes: 23 Carlo Cudicini, 2 Branislav Ivanovic, 19 Paulo Ferreira, 33 Alex, 35 Juliano Belletti, 43 Miroslav Stoch, 9 Franco Di Santo.
Roma are expected to line-up in the following 4-3-3 formation:
Doni; Cicinho, Panucci(c), Mexes, Riise; De Rossi, Aquilani Brighi; Taddei, Totti, Vucinic.
Subs: Artur, Loria, Okaka Chuka, Tonetto, Perotta, Menez, Montella.
The referee is Kyros Vassaras is from Greece.
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